Duodenal Ulcer

Authored by , Reviewed by Dr John Cox on | Certified by The Information Standard

A duodenal ulcer is usually caused by an infection with a germ (bacterium) called Helicobacter pylori (H. pylori). A 4- to 8-week course of acid-suppressing medication will allow the ulcer to heal. In addition, a one-week course of two antibiotics plus an acid-suppressing medicine will usually clear the H. pylori infection. This usually prevents the ulcer from coming back. Anti-inflammatory medicines used to treat conditions such as arthritis sometimes cause duodenal ulcers. If you need to continue with the anti-inflammatory medicine then you may need to take long-term acid-suppressing medication.

A duodenal ulcer is an ulcer that occurs in the lining in the part of the small intestine just beyond the stomach (the duodenum). An ulcer in the lining of the stomach is called a gastric ulcer.

There are separate leaflets called Non-ulcer Dyspepsia (Functional Dyspepsia), Stomach Ulcer (Gastric Ulcer) and Acid Reflux and Oesophagitis.

  • Pain in the upper tummy (abdomen) just below the breastbone (sternum) is the common symptom. It usually comes and goes. It may occur most before meals, or when you are hungry. It may be eased if you eat food, or take antacid tablets. The pain may wake you from sleep.
  • Other symptoms which may occur include bloating, retching, and feeling sick. You may feel particularly full after a meal. Sometimes food makes the pain worse.
  • Complications occur in some cases and can be serious. These include:
    • Bleeding ulcer. This can range from a trickle to a life-threatening bleed.
    • Perforation. The ulcer goes right through (perforates) the wall of the first part of the small intestine (duodenum). Food and acid in the duodenum then leak into the abdominal cavity. This usually causes severe pain and is a medical emergency.

General advice

Lifestyle measures can improve symptoms, such as:

Acid-suppressing medication

The most commonly used medicine is a proton pump inhibitor (PPI). See the separate leaflet called Indigestion Medication for more information.

If your ulcer was caused by H. pylori

Nearly all duodenal ulcers are caused by infection with H. pylori. See the separate leaflet called Stomach Pain (Helicobacter Pylori) for more information.

If your ulcer was caused by an anti-inflammatory medicine

If possible, you should stop the anti-inflammatory medicine. This allows the ulcer to heal. You will also normally be prescribed an acid-suppressing medicine for several weeks (see above).

Surgery

Surgery is now usually only needed if a complication of a duodenal ulcer develops, such as severe bleeding or a hole (perforation). 

There is normally a balance between the amount of acid that you make and the mucous defence barrier. An ulcer may develop if there is an alteration in this balance, allowing the acid to damage the lining of the stomach or duodenum. Causes of this include the following:

Infection with H. pylori

Infection with H. pylori is the cause in about 19 in 20 cases of duodenal ulcer. More than a quarter of people in the UK become infected with H. pylori at some stage in their lives. See the separate leaflet called Stomach Pain (Helicobacter Pylori) for more information.

Anti-inflammatory medicines - including aspirin

Anti-inflammatory medicines are sometimes called non-steroidal anti inflammatory drugs (NSAIDs). These medicines sometimes affect the mucous barrier of the duodenum and allow acid to cause an ulcer.

Other causes and factors

Other causes are rare. For example, the Zollinger-Ellison syndrome. In this rare condition, much more acid than usual is made by the stomach.

Other factors such as smoking, stress and drinking heavily may possibly increase the risk of having a duodenal ulcer. However, these are not usually the underlying cause of duodenal ulcers.

Further reading and references

  • ; NICE Clinical Guideline (Sept 2014)

  • ; History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014 May 1420(18):5191-204. doi: 10.3748/wjg.v20.i18.5191.

  • ; NICE CKS, September 2017 (UK access only)

When to worry about indigestion

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