Zika virus has quickly changed from a rare illness to the subject of international headlines. You can catch Zika virus if you are bitten by an affected mosquito. It is currently widespread in parts of South and Central America and the Caribbean region. Zika virus is usually a very mild illness. However, it is possibly the cause of birth defects in babies born to mothers who have the infection in pregnancy. It may also cause other complications. Concern about the possible link of these conditions with Zika virus led the World Health Organization (WHO) to declare it a public health emergency of international concern. There is much research urgently being done to discover more about Zika virus, its complications and how to prevent it.
What is Zika virus?
Zika virus is a type of germ. It is carried by a particular type of mosquito (Aedes aegypti). If you are bitten by this type of mosquito, you could become infected with Zika virus. For most people, this causes a very mild illness. You may not even be aware you have Zika virus.
The Aedes mosquito tends to bite during the daytime. This is different to the mosquitoes which transmit certain other infections such as malaria, which bite at night.
The Aedes mosquito can also carry other infections, such as chikungunya fever and dengue fever. These infections tend to occur in the same parts of the world, where this particular mosquito is mostly found.
Zika virus was first found in Africa in 1947. Until 2013 it was not at all common and not found in many countries. However, it started to spread across the world and in 2015 there was an outbreak in a number of places. The areas mainly affected are South America (especially Brazil and Columbia), Central America, the Pacific region and many of the Caribbean islands. It is possible that the virus may change (adapt) in the future, so it could be carried by another type of mosquito found in North America.
How common is Zika virus?
It is not known how many people have been affected by Zika virus since the outbreak started. This is because the illness is usually so mild that most people affected probably do not report it to their doctor. However, in Brazil it was thought there were over one and a half million cases in 2015, and in Columbia 25,000.
How could I become infected with Zika virus?
You can catch Zika virus if you travel to a country where there is known to be Zika virus infection, and are bitten by an infected mosquito. The weather in the UK is not warm enough for these mosquitoes to survive, so you cannot catch Zika virus from a bite in the UK.
Usually infection occurs by a mosquito bite. However, there are other ways in which it is, rarely, possible to become infected:
- Through having sex with a person who is infected with Zika virus.
- Through blood donation from a person who is infected with Zika virus. (In the UK, people who have travelled to countries with Zika virus cannot give blood for 28 days to prevent this happening.)
- Through the placenta. It seems to be possible for pregnant mothers to pass the virus on to babies in the womb (uterus).
What are the symptoms of Zika virus?
In most people, Zika virus is very mild. In fact, most people have no symptoms at all and do not know they have had the virus. If symptoms do occur, they usually start 3-12 days after a bite from an infected mosquito. Symptoms may include (but do not always include):
- A high temperature (fever).
- Aches in muscles and joints.
- Painful eyes or red itchy eyes.
- An itchy rash.
- Feeling weak and tired.
Other less common symptoms have also been reported, such as swelling in the legs and tummy upsets. Symptoms normally last just a few days.
Is there a test for Zika virus?
A blood test can confirm whether you have Zika virus. It has to be sent away to a special laboratory which tests for rare infections. If you are pregnant, a test of your urine is also done. In the UK, your blood will only be tested if you have typical Zika virus symptoms and have returned from a country where Zika virus is known to be common within the previous two weeks.
How is Zika virus treated?
Normally no treatment at all is needed. If you have a headache or high temperature (fever), or aches and pains, a medicine such as paracetamol or ibuprofen may help. Drink plenty of fluids and generally take the measures you would with any other mild virus infection.
If you are pregnant and contract Zika virus, you will need extra check-ups and tests. See the section below about Zika virus in pregnancy.
What are the complications of Zika virus?
This is not known for sure but is why Zika virus has been making news headlines. The worry is that babies born to mothers who have Zika virus in pregnancy may develop birth defects as a result. Also, it seems a few people with Zika virus go on to have other complications. None of this is yet definite, but there was enough evidence for the World Health Organization (WHO) to declare Zika a "public health emergency of international concern" in February 2016. This means that research into Zika is made a priority and that countries share all information, so that the outbreak can be tackled more effectively.
In Brazil it was noticed that there were twenty times as many babies as usual born with a particular birth defect during the time when there was a Zika virus outbreak. The most common defect was a condition where the baby was born with a smaller head and less developed brain (microcephaly).
Some evidence suggests this occurred as a result of Zika virus infection in the mother in early pregnancy - for example:
- Zika virus has been found in the fluid around the baby in the womb (amniotic fluid) in some cases where the mother has had the infection. It has also been found in brain tissue of babies who died as a result of their condition and whose mothers had had Zika virus infection in pregnancy.
- The increase in numbers of cases of babies with microcephaly coincided with the timing of the outbreak of Zika virus.
- Certain other viruses are known to cause abnormalities in developing babies.
However, other countries with Zika virus outbreaks have not had the same increase in babies born with microcephaly. Also, when many of the babies were examined further, they were found not to have microcephaly. Urgent research is being done to find out if Zika virus is causing babies to be born with microcephaly or not.
Guillain-Barré syndrome (GBS)
Guillain-Barré Syndrome (GBS) is an uncommon condition which affects the nerves of the limbs and body. It is usually triggered by an infection. The main symptom is weakness of the muscles that are supplied by the affected nerves. More cases of GBS have been noted in areas of Zika outbreaks in several countries. A study of 42 cases of GBS during the 2013 outbreak in French Polynesia found that all had had Zika virus infection.
Other complications are rare. Occasionally people infected with Zika virus may go on to have brain infections, such as meningitis.
What should I do if I am pregnant?
While the effects of Zika virus on an unborn baby are not known, it is sensible to be extremely cautious. Authorities in affected countries are advising women to avoid pregnancy during a Zika virus outbreak until there is more information about the risk.
For women in the UK, advice is as follows:
- If you are pregnant, avoid travel to a country known to have Zika virus. A list of affected countries is available and updated regularly on the Public Health England website and the European Centre for Disease Prevention and Control website (see under further help and information below) .
- If you are pregnant, avoid unprotected sex with a man who has visited a country affected by Zika virus for 28 days after return. Use condoms or do not have sex. If the man has had a probable or confirmed infection with Zika virus, current advice is to avoid unprotected sex for six months. This advice will be updated as more information becomes available.
- If you have travelled to an area with Zika virus, avoid becoming pregnant for 28 days.
- If you are pregnant and have returned from a country with Zika virus, let your GP, midwife or obstetrician know as soon as possible. An obstetrician is a doctor who specialises in pregnancy and childbirth. If you have, or have had, symptoms of Zika virus, a blood test and urine test will be arranged. You will have extra checks (for example, ultrasound scans) if you have recently travelled to a country with Zika virus. These will be carried out even if you did not have any symptoms of infection. This is a precaution because many people affected by Zika virus do not have symptoms and do not know they have had the illness. You and your baby will be monitored carefully through your pregnancy.
How can I avoid Zika virus?
You can avoid Zika virus infection by avoiding travelling to countries where it is known to occur. If you are travelling to a country which has Zika virus, take precautions to avoid being bitten by a mosquito. For example:
- Wear light clothing which covers your arms and legs, both in the day and the evening.
- Use a good mosquito repellent, and apply it regularly. Insect repellents containing the chemical N,N-diethylmetatoluamide (DEET) are the most effective. Re-apply the insect repellent after swimming. If you are using suntan lotion, use suntan lotion first and then apply the insect repellent over the suntan lotion. The repellent may make the sunscreen less effective, so use a sunscreen with sun protection factor (SPF) 30-50.
- If staying in buildings without mosquito screens on the windows and doors, sleep under a mosquito net. Check there are no holes in the net and repair any if necessary.
Specific advice for prevention in pregnant women is discussed in the section above.
Internationally, much work is being done to try to prevent the Zika virus spreading. Measures include:
- Research into a vaccine is taking place.
- Countries are sharing the information they gather about Zika virus and its complications.
- Journals are providing free access to studies done and articles written about Zika virus.
- Getting rid of mosquito breeding grounds. Mosquitoes breed in standing water, so areas or structures which allow water to stand are altered.
- Spraying areas with insecticide.
- Genetically altered mosquitoes have been produced. The idea is these mosquitoes breed with the population of infected mosquitoes and make them infertile. In this way the numbers of mosquitoes should drop.
Further reading and references
; Public Health England
; World Health Organization, September 2016
; Zika virus. BMJ. 2016 Feb 26352:i1049. doi: 10.1136/bmj.i1049.
; Royal College of Obstetricians and Gynaecologists, January 2016
; European Centre for Disease Prevention and Control (ECDC) (including epidemiological updates)
; British Medical Journal (BMJ)
; Travel Health Pro
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