Topical dose delivery in the reptilian egg treatment model. Expression of AR is higher in gonads from embryos incubated at female-determining temperatures than in embryos at male-determining temperatures. The evolutionary dynamics of sex determination. These findings demonstrate that androgens and AR regulate aromatase and FOXL2 expression in embryonic gonads and that correlated expression of aromatase and FOXL2 is due, in part, to the pleiotropic effects of AR a transcription factor.
In temperature-dependent sex determination, however, it is the environmental temperature during a critical period of embryonic development that determines whether an egg develops as male or female. Androgens have been shown to regulate aromatase in other species, but the androgen-AR-FOXL2 pathway is a novel regulatory interaction that has never been described in any species.
They did so to test the predictions of the Charnov-Bull model. Here, we use temperature-dependent expression profiles for 3 genes and a simple statistical method to illustrate one method for modeling gene regulatory networks. Support Center Support Center. Mol Syst Biol.
This primordium, also called the genital ridge, forms as an outgrowth of cells from the mesonephric portion of the embryonic kidney. Ann Rev Genet. Zool Sci. Gene function can be regulated by post-transcriptional mechanisms i.
One possible explanation that TSD is common in amniotes is phylogenetic inertia — TSD is the ancestral condition in this clade and is simply maintained in extant lineages because it is currently adaptively neutral or nearly so. Help Community portal Recent changes Upload file.
Biol Reprod. The extent of the TSP varies a little among species,  and development within the oviducts must be taken into account in species where the embryo is at a relatively late stage of development on egg laying e. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance.
Expression of Dmrt1 in a turtle with temperature-dependent sex determination.